Pre-prints

Bacterial Schlafens mediate anti-phage defense
V. Perez Taboada, Y. Wu, R. Cassidy, K.E. Medvedev, L. Loeff, A. Nemudraia#, A. Nemudryi#
BioRxiv, 2025, In Revision PMID: PMC12330615

2025

Mechanistic basis for PYROXD1-mediated protection of the human tRNA ligase complex against oxidative inactivation
L. Loeff, A. Kroupova, I. Asanović, F. Boneberg, M. Pfleiderer, Luca Riermeier, Alexander Leitner, A. Ferdigg, F. Ackle, J. Martinez & M. Jinek#
Nature Structural & Molecular Biology, 32, 1205–1212, 2025 PMID: 40069351

DNA end sensing and cleavage by the Shedu anti-phage defense system
L. Loeff#, A. Walter, G. Rosalen & M. Jinek#
Cell, 188, 721–733, 2025 PMID: 39742808

2024

Molecular mechanism of plasmid elimination by the DdmDE defense system
L. Loeff#, D. Adams, C. Chanez, S. Stutzmann, L. Righi, M. Blokesch & M. Jinek#
Science, 385, pp. 188-194, 2024 PMID: 38870273

2022

R-loop formation and conformational activation mechanisms of Cas9
M. Pacesa, L. Loeff*, L. Muckenfuss*, I. Querques*, M. Sawicka & M. Jinek#
Nature, 1-6, 2022 PMID: 36002571

2021

A fast and automated step detection method for analysing single-molecule trajectories
L. Loeff*, J. Kerssemakers*, C. Joo# & C. Dekker#
Patterns, 2 (5) 100256, 2021 PMID: 34036291

2020

Selective loading and processing of prespacers for precise CRISPR adaptation
S. Kim*#, L. Loeff*, S Colombo, S Jergic, SJJ Brouns, C Joo#
Nature, 579 (7797), 141-145, 2020 PMID: 32076262

2019

Biophysics of RNA-guided CRISPR adaptive immunity
L. Loeff & C Joo#
Springer Book: “Biophysics of RNA-Protein Interactions", ISBN: 978-1-4939-9724-4

2018

Repetitive DNA reeling by the Cascade-Cas3 complex in nucleotide unwinding steps
L. Loeff, SJJ Brouns, C Joo#
Molecular Cell, 70:1–10, 2018 PMID: 29706536

2016

Single-molecule pull-down for investigating protein–nucleic acid interactions
M. Fareh, L. Loeff, M. Szczepaniak, A.C. Haagsma, K. Yeom & C. Joo#
Methods, 105:99-108, 2016 PMID: 27017911

2015

TUT7 controls the fate of precursor microRNAs by using three different uridylation mechanisms
B. Kim*, M. Ha*, L. Loeff*, H. Chang, D. Simanshu, S. Li, M. Fareh, D.J. Patel, C. Joo#, & V.N. Kim#
EMBO Journal, 34(13):1801-15, 2015 PMID: 25979828

Two distinct DNA binding modes guide dual roles of a CRISPR-Cas protein complex
T. R. Blosser*, L. Loeff*, E.R. Westra, M. Vlot, T. Künne, M. Sobota, C. Dekker, S.J.J. Brouns# & C. Joo#
Molecular Cell, 58(1):60-70, 2015 PMID: 25752578

* Equal contribution | # Corresponding author