Microbial Immunity Laboratory

News

02 February 2026

We are pleased to welcome Ellen Zwiers!

19 January 2026

We are pleased to welcome Pilar Bobadilla Ugarte!

12 December 2025

The first sub-3 Å cryo-EM reconstruction has been obtained!

17 November 2025

Luuk presents at the Kroese-Duijsters symposium in Leiden (link).

21 October 2025

A big day for the lab: our first cryo-EM structure solved in house!

Also see News Archive

Research Focus

Our laboratory uses an integrative approach that combines single-molecule biophysics, cryogenic-electron microscopy, biochemistry to study immune mechanisms and harness them as genome engineering tools. Learn more!

Selected publications

DNA end sensing and cleavage by the Shedu anti-phage defense system
L. Loeff#, A. Walter, G. Rosalen & M. Jinek#
Cell, 188, 721–733, 2025

Molecular mechanism of plasmid elimination by the DdmDE defense system
L. Loeff#, D. Adams, C. Chanez, S. Stutzmann, L. Righi, M. Blokesch & M. Jinek#
Science, 385, pp. 188-194, 2024

Selective loading and processing of prespacers for precise CRISPR adaptation
S. Kim*#, L. Loeff*, S Colombo, S Jergic, SJJ Brouns, C Joo#
Nature, 579 (7797), 141-145, 2020

Repetitive DNA reeling by the Cascade-Cas3 complex in nucleotide unwinding steps
L. Loeff, SJJ Brouns, C Joo#
Molecular Cell, 70:1–10, 2018