Loeff Laboratory

News

18 August 2025
The Loeff laboratory opens its doors at the LUMC in Leiden.

18 July 2025
Luuk was selected for the LUMC Junior PI talent programme (link).

Also see News Archive

Research Focus

Our laboratory uses an integrative approach that combines single-molecule biophysics, cryogenic-electron microscopy, biochemistry to study immune mechanisms and harness them as genome engineering tools. Learn more!

Selected publications

DNA end sensing and cleavage by the Shedu anti-phage defense system
L. Loeff#, A. Walter, G. Rosalen & M. Jinek#
Cell, 188, 721–733, 2025

Molecular mechanism of plasmid elimination by the DdmDE defense system
L. Loeff#, D. Adams, C. Chanez, S. Stutzmann, L. Righi, M. Blokesch & M. Jinek#
Science, 385, pp. 188-194, 2024

Selective loading and processing of prespacers for precise CRISPR adaptation
S. Kim*#, L. Loeff*, S Colombo, S Jergic, SJJ Brouns, C Joo#
Nature, 579 (7797), 141-145, 2020

Repetitive DNA reeling by the Cascade-Cas3 complex in nucleotide unwinding steps
L. Loeff, SJJ Brouns, C Joo#
Molecular Cell, 70:1–10, 2018